Publication Progress

From BrothersBrothers

Manuscripts in Progress

In Preparation

Revise and Resubmit Pending

Submitted or Resubmitted

Accepted or In Press

Online AHOP

The Precision Medicine Initiative Cohort and the Ethics of Networked Biorepositories (Senior Author)

Peer-Reviewed Publications:

Original Research Articles:

1.Brothers KB. Covenant and the Vulnerable Other. Journal of the American Medical Association. 2002; 288 (9) : 1133.
2.Bryant KA, Humbaugh K, Brothers KB, Wright J, Pascual FB, Moran J, Murphy TV. Measures to Control an Outbreak of Pertussis in a Neonatal Intermediate Care Nursery After Exposure to a Healthcare Worker. Infection Control and Hospital Epidemiology. 2006; 27 (6) : 542-545.
3.Brothers KB, Glascoe FP, Robertshaw NS. PEDS: Developmental Milestones--an accurate brief tool for surveillance and screening. Clinical Pediatrics. 2008; 47 (3) : 271-279.
4.Bishop JP, Brothers KB, Perry JE, Ahmad A. Reviving the conversation around CPR/DNR. American Journal of Bioethics. 2010; 10 (1) : 61-67.
5.Brothers KB, Clayton EW. “Human Non-Subjects Research”: Privacy and Compliance. American Journal of Bioethics. 2010; 10 (9) : 15-17.
6.Langanke M, Brothers KB, Erdmann P, Weinert J, Krafczyk-Korth J, Dorr M, Hoffmann W, Kroemer H, Assel H. Comparing different scientific approaches to personalized medicine: research ethics and privacy protection. Personalized Medicine. 2011; 8 (4) : 437-444.
7.Brothers KB. Biobanking in Pediatrics: The Human Non-Subjects Approach. Personalized Medicine. 2011; 8 (1) : 71-79.
8.Brothers KB. Dependent Rational Providers. Journal of Medicine and Philosophy. 2011; 36 (2) : 133-147.
9.Brothers KB, Morrison DM, Clayton EW. Two Large Scale Surveys on Community Attitudes Toward an Opt-Out Biobank. American Journal of Medical Genetics. 2011; 155A (12) : 2982-2990.
10.Fullerton SM, Wolf WA, Brothers KB, Clayton EW, Crawford DC, Denny JC, Greenland P, Koenig BA, Leppig KA, Lindor NM, McCarty CA, McGuire AL, McPeek Hinz ER, Mirel DB, Ramos EM, Ritchie MD, Smith ME, Waudby CJ, Burke W, Jarvik GP. Return of Individual Research Results from Genome-wide Association Studies: Experience of the Electronic Medical Records and Genomics (eMERGE) Network. Genetics in Medicine. 2012; 14 (4) : 424-431.
11.Brothers KB, Clayton EW. Parental Perspectives on a Pediatric Human Non-Subjects Biobank. American Journal of Bioethics: Primary Research. 2012; 3 (3) : 21-29.
12.Pulley JM, Denny JC, Peterson JF, Bernard GR, Vnencak-Jones CL, Ramirez AH, Delaney JT, Bowton E, Brothers KB, Johnson K, Crawford DC, Schildcrout J, Masys DR, Dilks H, Clayton EW, Schultz E, Laposata M, McPherson J, Jirjis JN, Roden DM. Operational implementation of prospective genotyping for personalized medicine: The design of the Vanderbilt PREDICT project. Clinical Pharmacology & Therapeutics. 2012; 92 (1) : 87-95.
13.Westbrook MJ, Wright MF, Van Driest SL, McGregor TL, Denny JC, Zuvich RL, Clayton EW, Brothers KB. Mapping the Incidentalome: Estimating Incidental Findings Generated Through Clinical Pharmacogenomics Testing. Genetics in Medicine. 2012; 15 (5) : 325-331.
14.Langanke M, Fischer T, Erdmann P, Brothers KB. Gesundheitliche Eigenverantwortung im Kontext Individualisierter Medizin (Personal Responsibility in the Context of Individualized Medicine). Ethik in der Medizin. 2012; 25 (13) : 243-250.
The content in this article overlaps with the content of a book chapter, originally published in English, that is also listed here. It was revised, updated, and translated into German at the invitation of the journal Ethik in der Medizin.
15.McGregor TL, Van Driest SL, Brothers KB, Bowton EA, Muglia LJ, Roden DM. Inclusion of pediatric samples in an opt-out biorepository linking DNA to de-identified medical records: Pediatric BioVU. Clinical Pharmacology & Therapeutics. 2013; 93 (2) : 204-211.
16.Rosenbloom ST, Madison JL, Brothers KB, Bowton EA, Clayton EW, Malin BA, Roden DM, Pulley J. Ethical and Practical Challenges to Studying Patients Who Opt Out of Large-Scale Biorepository Research. Journal of the American Medical Informatics Association. 2013; 20: e221-e225.
17.Webster THG, Beal SJ, Brothers KB. Motivation in the Age of Genomics: Why Incidental Genetic Findings of Disease Susceptibility Might Not Motivate Behavior Change. Life Sciences, Society, and Policy. 2013; 9 (8) .
18.Brothers KB, Westbrook MJ, Wright MF, Myers JA, Morrison DR, Madison JL, Pulley JM, Clayton EW. Patient Awareness and Approval for an Opt-Out Genomic Biorepository. Personalized Medicine. 2013; 10 (4) : 349-359.
19.Brothers KB, Langanke M, Erdmann P. The Implications of the Incidentalome for Clinical Pharmacogenomics. Pharmacogenomics. 2013; 14 (11) : 1353-1362.
20.Hazin R, Brothers KB, Malin BA, Koenig BA, Sanderson S, Rothstein MA, Williams MS, Clayton EW, Kullo IJ. Ethical, Legal and Social Implications of Incorporating Genomic Information into Electronic Health Records. Genetics in Medicine. 2013; 15 (10) : 810-816.
21.Jarvik GP, Amendola LM, Berg JS, Brothers KB, Clayton EW, Chung W, Evans BJ, Evans JP, Fullerton SM, Gallego CJ, Garrison NA, Gray SW, Holm IA, Kullo IJ, Lehmann LS, McCarty C, Prows CA, Rehm HL, Sharp RR, Salama J, Sanderson S, Van Driest SL, Williams MS, Wolf SM, Wolf WA, eMERGE ROR Committee & CERC Committee, CSER Act-ROR Working Group, Burke W. Return of Genomic Results to Research Participants: The floor, the ceiling, and the choices in-between. The American Journal of Human Genetics. 2014; 94 (6) : 818-826.
22.Van Driest SL, McGregor TL, Velez-Edwards DR, Saville BR, Kitchner TE, Hebbring SJ, Brilliant M, Jouni H, Kullo IJ, Creech CB, Kannankeril PJ, Vear SI, Brothers KB, Bowton EA, Shaffer CM, Patel N, Delaney JT, Bradford Y, Wilson S, Olson L, Crawford DC, Ho R, Potts AL, Ho RH, Roden DM, Denny JC. Genome-Wide Association Study of Serum Creatinine Levels during Vancomycin Therapy. PLOS One. 2014.
23.Brothers KB, Lynch JA, Aufox SA, Connolly JJ, Gelb BD, Holm IA, Sanderson SC, McCormick JB, Williams JL, Wolf WA, Antommaria AHM, Clayton EW. Practical Guidance on Informed Consent for Pediatric Participants in a Biorepository. Mayo Clinic Proceedings. 2014; 89 (11) : 1471-1480.
24.Brothers KB, Rothstein MA. Ethical, Legal, and Social Implications of Incorporating Personalized Medicine into Healthcare. Personalized Medicine. 2015; 12 (1) : 43-51.
25.Khan CM, Rini C, Bernhardt BA, Roberts JS, Christensen KD, Evans JP, Brothers KB, Roche MI, Berg JS, Henderson GE. How Can Psychological Science Inform Research About Genetic Counseling for Clinical Genomic Sequencing?. Journal of Genetic Counseling. 2015; 24 (2) : 193-204.
26.McCullough LB, Brothers KB, Chung WK, Joffe S, Koenig BA, Wilfond BS, Yu JH. Professionally Responsible Disclosure of Genomic Sequencing Results in Pediatric Practice. Pediatrics. 2015; 136 (4) : e974-82.
27.Brothers KB, Holm IA, Childerhose JE, Antommaria AHM, Bernhardt BA, Clayton EW, Gelb BD, Joffe S, Lynch JA, McCormick JB, McCullough LB, Parsons DW, Sundaresan AS, Wolf WA, Yu JH, Wilfond BS. When Participants in Genomic Research Grow Up: Contact and Consent at the Age of Majority. The Journal of Pediatrics. 2016; 168 (January) : 226-231.e1.
28.Shaffer LA, Brothers KB, Burkhead TA, Yeager R, Myers JA, Sweeney BR. Factors Associated with Attendance after Referral to a Pediatric Weight Management Program. Pediatrics. 2016; 172 (May) : 35-39.
29.Green RC, Goddard KAB, Amendola LM, Appelbaum PS, Berg JS, Bernhardt B, Biesecker LG, Blout CL, Bowling KM, Brothers KB, Burke W, Caga-Anan CF, Chinnaiyan AM, Chung WK, Clayton EW, Cooper G, East K, Evans JP, Fullerton M, Garraway LA, Garrett JR, Gray SW, Henderson GE, Hindorff LA, Holm IA, Huckaby-Lewis MA, Hutter CM, Janne PA, Jarvik GP, Joffe S, Kaufman D, Knoppers BM, Koenig BA, Krantz ID, Manolio T, McCullough L, McEwen J, McGuire A, Muzny D, Myers RM, Nickerson D, Ou J, Parsons DW, Petersen GM, Plon SE, Rehm H, Roberts JS, Robinson D, Salama JS, Scollon S, Sharp RR, Shirts B, Spinner NB, Tabor HK, Tarczy-Hornoch P, Veenstra D, Wagle N, Weck K, Wilfond BS, Wilhelmsen K, Wolf SR, Wynn J, Yu JH. The Clinical Sequencing Exploratory Research Consortium: Accelerating the Evidence-Based Practice of Genomic Medicine. American Journal of Human Genetics. 2016; 98 (6) : 1051-1066.
30.Fischer T, Brothers KB, Erdman P, Langanke M. Clinical Decision-Making and Secondary Findings in Systems Medicine. BMC Medical Ethics. 2016; 17 (32) : 1-12.
31.Smith ME, Sanderson SC, Brothers KB, Myers MF, McCormick J, Aufox SA, Schrubsole MJ, Garrison NA, Mercaldo N, Schildcrout JS, Clayton EW, Antommaria AHM, Basford M, Brilliant M, Connolly JJ, Fullerton SM, Horowitz CR, Jarvik GP, Kaufman D, Kitchner T, Li R, Ludman EJ, McCarty C, McManus V, Stallings SC, Williams JL, Holm IA. Conducting a Large, Multi-Site Survey about Patients' Views on Broad Consent: Challenges and Solutions. BMC Medical Research Methodology. 2016; 16 (1) : 162.
32.Brothers KB, Goldenberg AJ. Ethical and Legal Considerations for Pediatric Biobank Consent: Current and Future Perspectives. Personalized Medicine. 2016; 13 (6) : 597-607.
33.Sanderson SC, Brothers KB, Mercaldo ND, Clayton EW, Antommaria AHM, Aufox SA, Brilliant MH, Campos D, Carrell DS, Connolly JJ, Conway P, Fullerton SM, Garrison NA, Horowitz CR, Jarvik GP, Kaufman D, Kitchner TE, Li R, Ludman EJ, McCarty C, McCormick J, McManus V, Myers MF, Scrol A, Williams J, Schrubsole MJ, Schildcrout JS, Smith ME, Holm IA. Public attitudes towards consent and data sharing in biobank research: a large multi-site experimental survey in the US. American Journal of Human Genetics. 2016; 100 (3) : 414-427.
34.Logsdon MC, Myers J, Rushton J, Gregg J, Josephson A, Davis D, Brothers KB, Baisch K, Vogt K, Jones K, Angermeier J. Efficacy of an Internet-Based Depression Intervention to Improve Rates of Treatment in Adolescent Mothers. Archives of Women's Mental Health. 2016; 21: 273-285.
35.Brothers KB, East KM, Kelley WV, Wright MF, Westbrook MJ, Rich CA, Bowling KM, Lose EJ, Bebin EM, Simmons S, Myers JA, Barsh G, Myers RM, Cooper GM, Pulley JM, Rothstein MA, Clayton EW. Eliciting Preferences on Secondary Findings: The Preferences Instrument for Genomic Secondary Results (PIGSR). Genetics in Medicine. 2017; 19 (3) : 337-344.
36.Lohr WD, Brothers KB, Davis DW, Rich CA, Ryan L, Smith M, Stevenson M, Feygin Y, Woods C, Myers JA, Liu GC. Providers’ Behaviors and Beliefs on Prescribing Antipsychotic Medication to Children: A Qualitative Study. Community Mental Health Journal. 2017; 54: 17-26.
37.Bowling KM, Thompson ML, Amaral MD, Finnila CR, Hiatt SM, Engel KL, Cochran JN, Brothers KB, East KM, Gray DE, Kelley WV, Lamb NE, Lose EJ, Rich CA, Simmons S, Whittle JS, Weaver BT, Nesmith AS, Myers RM, Barsh GS, Bebin EM, Cooper GM. Genomic diagnosis for children with intellectual disability and/or developmental delay. Genome Medicine. 2017; 9 (43) : 1-11.
38.Biesecker BB, Woolford SW, Klein WMP, Brothers KB, Umstead KL, Lewis KL, Biesecker LG, Han PKJ. PUGS: A novel scale to assess perception of uncertainties in genome sequencing. Clinical Genetics. 2017; 92 (2) : 172-179.
39.Antommaria AHM, Brothers KB, Myers JA, Feygin Y, Aufox SA, Brilliant MH, Conway P, Fullerton SM, Garrison NA, Horowitz CR, Jarvik GP, Li R, Ludman EJ, McCarty CA, McCormick JB, Mercaldo ND, Myers MF, Sanderson SC, Shrubsole MJ, Schildcrout JS, Williams JL, Smith ME, Clayton EW, Holm IA. Parents' Attitudes toward Consent and Data Sharing in Biobanks: A Multisite Experimental Survey. AJOB Empirical Bioethics. 2017; 9 (3) : 128-142.
40.Hiatt SM, Amaral MD, Bowling KM, Finnila CR, Thompson ML, Gray DE, Cochran JN, Bebin EM, Brothers KB, East KM, Kelley WV, Lamb NE, Lawlor JMJ, Levy SE, Lose EJ, Neu MB, Rich CA, Simmons S, Myers RM, Barsh GS, Cooper GM. Systematic reanalysis of genomic data improves quality of variant interpretation. Clinical Genetics. 2018; 94 (1) : 174-178.
41.Thompson ML, Finnila CR, Bowling KM, Brothers KB, Neu MB, Amaral MD, Hiatt SM, East KM, Gray DE, Lawlor JMJ, Kelley WV, Myers RM, Barsh GS, Bebin EM, Cooper GM. Genomic sequencing identifies secondary findings in a cohort of parent study participants. Genetics in Medicine. 2018; 20 (12) : 1635-1643.
42.Minari J, Morrison M, Brothers KB. Tensions in Ethics and Policy Created by National Precision Medicine Programs. Human Genomics. 2018; 12 (1) : 1-10.
43.Brothers KB, Knapp E. Case 2: How Should Primary Care Physicians Respond to Direct-to-consumer Genetic Test Results?. AMA Journal of Ethics. 2018; 20 (9) : E812-818.
44.Brothers KB, Wilfond BS. Research Consent at the Age of Majority: Preferable but not Obligatory. Pediatrics. 2018; 142 (2) : e20173038.
45.Garrison NA, Brothers KB, Goldenberg AJ, Lynch JA. Genomic Contextualism: Shifting the Rhetoric of Genetic Exceptionalism. American Journal of Bioethics. 2018; 19 (1) : 51-63.
46.Brothers KB, Vassy JL, Green RC. Reconciling Opportunistic and Population Screening in Clinical Genomics. Mayo Clinic Proceedings. 2019; 94 (1) : 103-109.
47.Lohr WD, Davis DW, Rich CA, Ryan L, Jones VF, Williams PG, Liu GC, Woods C, Sonderman N, Pasquenza N, Brothers KB. Addressing the Mental Healthcare Needs of Foster Children: Perspectives of Stakeholders from the Child Welfare System. Journal of Public Child Welfare. 2019; 13 (1) : 84-100.
48.Pet DB, Holm IA, Williams JL, Myers MF, Novak LL, Brothers KB, Wiesner GL, Clayton EW. Physicians' Perspectives on Receiving Unsolicited Genomic Results. Genetics in Medicine. 2019; 21 (2) : 311-318.
49.Mercaldo ND, Brothers KB, Carrell DS, Clayton EW, Connolly JJ, Holm IA, Horowitz CR, Jarvik GP, Kitchner TE, Li R, McCarty CA, McCormick JB, McManus VC, Myers MF, Pankratz JJ, Shrubsole MJ, Smith ME, Stallings SC, Williams JL, Schildcrout JS. Enrichment sampling for a multi-site patient survey using electronic health records and census data. Journal of American Medical Informatics Association. 2019; 26 (3) : 219-227.
50.Ormond KE, Hallquist MLG, Buchanan AH, Dondanville D, Cho MK, Smith ME, Roche M, Brothers KB, Coughlin CR, Hercher L, Hudgines L, Jamal S, Levy HP, Stosic M, Uhlmann W, Wain KE, Currey E, Faucett WA. Developing a Conceptual, Reproducible, Rubric-Based Approach to Consent and Result Disclosure for Genetic Testing by Clinicians with Minimal Genetics Background. Genetics in Medicine. 2019; 21 (3) : 727-735.
51.Brothers KB, Rivera SM, Cadigan RJ, Sharp RR, Goldenberg AJ. A Belmont Reboot: Building a Normative Foundation for Human Research in the 21st Century. The Journal of Law, Medicine, and Ethics. 2019; 47 (1) : 165-172.
52.Bombard Y, Brothers KB, Fitzgerald-Butt S, Garrison NA, Jamal L, James CA, Jarvik GP, McCormick JB, Nelson TN, Ormond KE, Rehm HL, Richer J, Souzeau E, Vassy JL, Wagner JK, Levy HP. ASHG Position Statement: The Responsibility to Recontact Research Participants After Reinterpretation of Genetic and Genomic Research Results. American Journal of Human Genetics. 2019; 104 (4) : 578-595.
53.Hart MR, Biesecker BB, Blout CL, Christensen KD, Amendola LM, Bergstrom KL, Biswas S, Bowling KM, Brothers KB, Conlin LK, Cooper GM, Dulik MC, East KM, Everett JN, Finnila CR, Ghazani AA, Gilmore MJ, Goddard KAB, Jarvik GP, Johnston JJ, Kauffman TL, Kelley WV, Krier JB, Lewis KL, McGuire AL, McMullen C, Ou J, Plon SE, Rehm H, Richards CS, Romasko EJ, Sagardia AM, Spinner NB, Thompson ML, Turbitt E, Vassy JL, Wilfond BS, Veenstra DL, Berg JS, Green RC, Biesecker LG, Hindorff LA. Secondary findings from clinical genomic sequencing: Prevalence, patient perspectives, family history assessment, and healthcare costs from a multi-site study. Genetics in Medicine. 2019; 21 (5) : 1100-1110.
54.Yu JH, Appelbaum P, Brothers KB, Joffe S, Kaufman T, Koenig B, Prince A, Scollon S, Wolf S, Bernhardt BA, Wilfond BS. Consent for clinical genome sequencing: Considerations from the Clinical Sequencing Exploratory Research Consortium. Personalized Medicine. 2019; 16 (4) : 325-333.
55.Childerhose JE, Finnila CR, Yu JH, Koenig BA, McEwen JE, Berg SL, Wilfond BS, Appelbaum PS, Brothers KB. Participant Engagement in Translational Genomic Research: Respect for Persons--and Then Some. Ethics & Human Research. 2019; 41 (5) : 2-15.
56.Garrett JR, Lantos JD, Biesecker LG, Childerhose JE, Chung WK, Holm IA, Koenig BA, McEwen JE, Wilfond BS, Brothers KB. Rethinking the “Open Future” Argument against Predictive Genetic Testing. Genetics in Medicine. 2019; 21 (10) : 2190-2198.
57.Robinson JO, Wynn J, Biesecker B, Biesecker L, Bernhardt B, Brothers KB, Chung WK, Christensen KD, Green RC, McGuire AL, Hart RM, Griesemer I, Patrick DL, Rini C, Veenstra D, Cronin AM, Gray SW. Psychological Outcomes Related to Exome and Genome Sequencing Result Disclosure: A Meta-Analysis of Seven Clinical Sequencing Exploratory Research (CSER) Consortium Studies. Genetics in Medicine. 2019; 21: 2781–2790.
58.Rothstein MA, Zawati MH, Beskow LM, Brelsford KM, Brothers KB, Hammack-Aviran CM, Hazel JW, Lang M, Patrinos D, Saltzman A, Knoppers BM. Legal and Ethical Challenges of International Direct-to-Participant Genomic Research: Conclusions and Recommendations. The Journal of Law, Medicine, and Ethics. 2020; 47 (Winter 2019) : 705-731.
59.Bibler TM, Stahl D, Fantus S, Lion A, Brothers KB. Responding to Parents/Guardians Who Hope for a Miracle: A Process-Based Approach. Pediatrics. 2020; 145 (3) : e20192319.
60.Brothers KB, Clayton EW, Goldenberg AJ. Online Pediatric Research: Addressing Consent, Assent, and Parental Permission. Journal of Law, Medicine, & Ethics. 2020; 48 (S1) : 129-137.
61.Rothstein MA, Wilbanks JT, Beskow LM, Brelsford KM, Brothers KB, Doerr M, Evans BJ, Hammack-Aviran CM, McGowan ML, Tovino SA. Unregulated Health Research Using Mobile Devices: Ethical Considerations and Policy Recommendations. Journal of Law, Medicine, & Ethics. 2020; 48 (S1) : 196-226.